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LEF1 antibody

CAT: 0710-FNab04745Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04745Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Participates in the Wnt signaling pathway. Activates transcription of target genes in the presence of CTNNB1 and EP300. May play a role in hair cell differentiation and follicle morphogenesis. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by LEF1 and CTNNB1. Regulates T-cell receptor alpha enhancer function. Binds DNA in a sequence-specific manner. PIAG antagonizes both Wnt-dependent and Wnt-independent activation by LEF1 (By similarity) . Isoform 3 lacks the CTNNB1 interaction domain and may be an antagonist for Wnt signaling. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells.
Synonyms
Lymphoid enhancer-binding factor 1 (LEF-1) |T cell-specific transcription factor 1-alpha (TCF1-alpha) |LEF1
Gene ID
51176
UniProt
Q9UJU2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Lymphoid enhancer-binding factor 1
Target
LEF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB, IP
Field of Research
Epigenetics, Cancer, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40-45 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB, IP

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