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IKZF1 antibody

CAT: 0710-FNab04204Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab04204Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription regulator of hematopoietic cell differentiation (PubMed:17934067) . Binds gamma-satellite DNA (PubMed:17135265, PubMed:19141594) . Plays a role in the development of lymphocytes, B-and T-cells. Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Repressor of the TDT (fikzfterminal deoxynucleotidyltransferase) gene during thymocyte differentiation. Regulates transcription through association with both HDAC-dependent and HDAC-independent complexes. Targets the 2 chromatin-remodeling complexes, NuRD and BAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis in adult erythroid cells. Confers early temporal competence to retinal progenitor cells (RPCs) (By similarity) . Function is isoform-specific and is modulated by dominant-negative inactive isoforms (PubMed:17135265, PubMed:17934067) .
Synonyms
DNA-binding protein Ikaros|Ikaros family zinc finger protein 1|Lymphoid transcription factor LyF-1|IKZF1|IK1|IKAROS|LYF1|ZNFN1A1
Gene ID
10320
UniProt
Q13422
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
IKAROS family zinc finger 1 (Ikaros)
Target
IKZF1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IP
Field of Research
Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
57-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IP

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