ARHGAP45 antibody

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ARHGAP45 antibody

CAT:

710-FNab03935

Size:

100 µg

Price:

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For price, please contact [email protected].

ARHGAP45 antibody

Background: GTPase activator for the Rho-type GTPases. Precursor of the histocompatibility antigen HA-1. More generally, minor histocompatibility antigens(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease(GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation(BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. Specifically, mismatching for mHag HA-1 which is recognized as immunodominant, is shown to be associated with the development of severe GVHD after HLA-identical BMT. HA-1 is presented to the cell surface by MHC class I HLA-A*0201, but also by other HLA-A alleles. This complex specifically elicits donor-cytotoxic T-lymphocyte(CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL.
Synonyms: Rho GTPase-activating protein 45|Minor histocompatibility antigen HA-1 (mHag HA-1)|ARHGAP45|HMHA1|KIAA0223
Gene ID: 23526
UniProt: Q92619
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: histocompatibility(minor) HA-1
Target: ARHGAP45
Clonality: Polyclonal
Isotype: IgG
Applications: ELISA, WB, IHC
Field of Research: Signal Transduction
Purification: Immunogen affinity purified
Dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Purity: ≥95% as determined by SDS-PAGE
Form: Liquid
Molecular Weight: 140-150 kDa
Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months(Avoid repeated freeze / thaw cycles.)

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