HGS antibody

Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex) . The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.

Hepatocyte growth factor-regulated tyrosine kinase substrate|Hrs|Protein pp110|HGS|HRS

9146

O14964

Human, Mouse

Hepatocyte growth factor-regulated tyrosine kinase substrate

HGS

ELISA, WB, IP, IF

Signal Transduction

Immunogen affinity purified

WB: 1:500-1:2000; IP: 1:200-1:1000; IF: 1:20-1:200

≥95% as determined by SDS-PAGE

Liquid

110-115 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)