HDAC4 antibody

• Background:

  Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.

• Synonyms:

  Histone deacetylase 4 (HD4) |HDAC4|KIAA0288

• Gene ID:

  9759

• UniProt:

  P56524

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Histone deacetylase 4

• Target:

  HDAC4

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Epigenetics, Cardiovascular, Metabolism, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:1000; IHC: 1:50 - 1:100

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  130 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC