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HCFC1 antibody

CAT: 0710-FNab03782Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03782Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Involved in control of the cell cycle. Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15 (INK4b) promoter and inhibits its ability to recruit p300. Coactivator for EGR2 and GABP2. Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription, respectively) together. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. In case of human herpes simplex virus (HSV) infection, HCFC1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and POU2F1 thereby enabling the transcription of the viral immediate early genes.
Synonyms
Host cell factor 1 (HCF, HCF-1) |C1 factor|CFF|VCAF|VP16 accessory protein|HCF N-terminal chain 1|HCF N-terminal chain 2|HCF N-terminal chain 3|HCF N-terminal chain 4|HCF N-terminal chain 5|HCF N-terminal chain 6|HCF C-terminal chain 1|HCF C-terminal chain 2|HCF C-terminal chain 3|HCF C-terminal chain 4|HCF C-terminal chain 5|HCF C-terminal chain 6|HCFC1|HCF1|HFC1
Gene ID
3054
UniProt
P51610
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Host cell factor C1 (VP16-accessory protein)
Target
HCFC1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
230 kDa, 300 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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