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GZMB antibody

CAT: 0710-FNab03737Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03737Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This enzyme is necessary for target cell lysis in cell-mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.
Synonyms
Granzyme B|C11|CTLA-1|Cathepsin G-like 1 (CTSGL1) |Cytotoxic T-lymphocyte proteinase 2 (Lymphocyte protease) |Fragmentin-2|Granzyme-2|Human lymphocyte protein (HLP) |SECT|T-cell serine protease 1-3E|GZMB|CGL1|CSPB|CTLA1|GRB
Gene ID
3002
UniProt
P10144
Host
Rabbit
Reactivity
Human
Immunogen
Granzyme B
Target
GZMB
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Cancer, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
33 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · P10144

Granzyme B

GRAB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P10144
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GZMB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.79
Processing
Precursor
Secondary accessions
Q8N1D2, Q9UCC1
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

ApoptosisCytolysis

PTM

Disulfide bondGlycoproteinZymogen

Molecular function

HydrolaseProteaseSerine protease

Cellular component

LysosomeSecreted

Domain

Signal

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