GPI antibody

This gene encodes a member of the glucose phosphate isomerase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. In the cytoplasm, the gene product functions as a glycolytic enzyme (glucose-6-phosphate isomerase) that interconverts glucose-6-phosphate and fructose-6-phosphate. Extracellularly, the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons, and as a lymphokine that induces immunoglobulin secretion. The encoded protein is also referred to as autocrine motility factor based on an additional function as a tumor-secreted cytokine and angiogenic factor. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment. Alternative splicing results in multiple transcript variants.

Glucose-6-phosphate isomerase (GPI) |Autocrine motility factor (AMF) |Neuroleukin (NLK) |Phosphoglucose isomerase (PGI) |Phosphohexose isomerase (PHI) |Sperm antigen 36 (SA-36) |GPI

2821

P06744

Human, Mouse, Rat

Glucose phosphate isomerase

GPI

ELISA, WB, IHC, IF

Metabolism, Cardiovascular, Cancer, Immunology, Neuroscience

Immunogen affinity purified

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

≥95% as determined by SDS-PAGE

Liquid

56 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)