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GNAI1 antibody

CAT: 0710-FNab03531Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03531Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins (PubMed:8774883, PubMed:18434541) . Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels (By similarity) . The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis (PubMed:17635935) .
Synonyms
Guanine nucleotide-binding protein G (i) subunit alpha-1|Adenylate cyclase-inhibiting G alpha protein|GNAI1
Gene ID
2770
UniProt
P63096
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
Target
GNAI1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, FC, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
40 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, FC, IF

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