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GATM antibody

CAT: 0710-FNab03368Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03368Size:100 µg
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Background
This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by mental retardation, language impairment, and behavioral disorders.
Synonyms
Glycine amidinotransferase, mitochondrial|L-arginine:glycine amidinotransferase|Transamidinase|GATM|AGAT
Gene ID
2628
UniProt
P50440
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Glycine amidinotransferase (L-arginine:glycine amidinotransferase)
Target
GATM
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
43 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · P50440

Glycine amidinotransferase, mitochondrial

GATM_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P50440
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GATM
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.1.4.1
Processing
Precursor
Secondary accessions
B4DH99, B4DPI3, Q53EQ4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion inner membrane

Disease

Disease variant

Molecular function

Transferase

Domain

Transit peptide

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