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GATA1 antibody

CAT: 0710-FNab03359Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03359Size:100 µg
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Background
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781) .
Synonyms
Erythroid transcription factor|Eryf1|GATA-binding factor 1 (GATA-1, GF-1) |NF-E1 DNA-binding protein|GATA1|ERYF1|GF1
Gene ID
2623
UniProt
P15976
Host
Mouse
Reactivity
Human, Mouse
Immunogen
GATA binding protein 1 (globin transcription factor 1)
Target
GATA1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism, Developmental biology, Neuroscience, Stem Cells
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
43 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9H0
Tested Applications
ELISA, WB
Immunogen Sequence
1-260aa

UniProtKB · P15976

Erythroid transcription factor

GATA1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P15976
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GATA1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q96GB8
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDNA-bindingRepressor

Coding sequence diversity

Alternative initiationAlternative splicing

Disease

Disease variantHereditary hemolytic anemia

Ligand

Metal-bindingZinc

Cellular component

Nucleus

Domain

RepeatZinc-finger

Biological process

TranscriptionTranscription regulation

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