GALE antibody

CAT: 0710-FNab03309Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab03309Size:100 µg
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Background
This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form) . Multiple alternatively spliced transcripts encoding the same protein have been identified.
Synonyms
UDP-glucose 4-epimerase|Galactowaldenase|UDP-N-acetylgalactosamine 4-epimerase (UDP-GalNAc 4-epimerase) |UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) |UDP-galactose 4-epimerase|GALE
Gene ID
2582
UniProt
Q14376
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
UDP-galactose-4-epimerase
Target
GALE
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
36 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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