Cariprazine (Standard)

CAT: 0804-HY-14763R-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-14763R-01Size:5 mg

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Description

Cariprazine (Standard) is the analytical standard of Cariprazine. This product is intended for research and analytical applications. Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM) .

CAS Number

839712-12-8

Product Name Alternative

RGH-188 (Standard)

UNSPSC

12352005

Target

5-HT Receptor; Dopamine Receptor; Reference Standards

Type

Reference Standards

Related Pathways

GPCR/G Protein; Neuronal Signaling; Others

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cariprazine-standard.html

Smiles

O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C

Molecular Formula

C21H32Cl2N4O

Molecular Weight

427.41

References & Citations

[1]Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl) . 2011 Dec;218 (3) :579-8|[2]Kiss B, et al. Cariprazine (RGH-188), a dopamine D (3) receptor-preferring, D (3) /D (2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333 (1) :328-40.|[3]Zimnisky R, et al. Cariprazine, a dopamine D (3) -receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl) . 2013 Mar;226 (1) :91-100|[4]Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3 (1) :e00073.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

Isoform

5-HT1 Receptor

Chemical Information

Cariprazine

Cariprazine is an N-alkylpiperazine that is N,N-dimethyl-N'-{trans-4-[2-(piperazin-1-yl)ethyl]cyclohexyl}urea substituted at position 4 on the piperazine ring by a 2,3-dichlorophenyl group. Used (as the hydrochloride salt) for treatment of schizophrenia and bipolar disorder. It has a role as a serotonergic antagonist, a dopamine agonist and a second generation antipsychotic. It is a dichlorobenzene, a N-alkylpiperazine, a N-arylpiperazine and a member of ureas. It is a conjugate base of a cariprazine(1+).

CAS Number	839712-12-8
PubChem CID	11154555
IUPAC Name	3-[4-[2-[4-(2,3-dichlorophenyl)piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethylurea
Molecular Formula	C21H32Cl2N4O
Molecular Weight	427.4
XLogP	4.3
Topological Polar Surface Area	38.8
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Heavy Atom Count	28
Formal Charge	0
Complexity	491

SMILES

CN(C)C(=O)NC1CCC(CC1)CCN2CCN(CC2)C3=C(C(=CC=C3)Cl)Cl

InChI

InChI=1S/C21H32Cl2N4O/c1-25(2)21(28)24-17-8-6-16(7-9-17)10-11-26-12-14-27(15-13-26)19-5-3-4-18(22)20(19)23/h3-5,16-17H,6-15H2,1-2H3,(H,24,28)

InChIKey

KPWSJANDNDDRMB-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 839712-12-8

CID: 11154555

Formula: C21H32Cl2N4O

MW: 427.4

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	427.4
XLogP3	4.3
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	426.1953170
Monoisotopic Mass	426.1953170
Topological Polar Surface Area	38.8 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	491
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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HY-14763A-01	Cariprazine (hydrochloride)
HY-100658-01	Didesmethyl cariprazine
HY-W716520-01	Cariprazine-d8-1
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A3282-5.1	Cariprazine

Cariprazine (Standard)

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