Cariprazine

• Description:

  Cariprazine is a novel antipsychotic agent candidate that exhibits high affinity for the D3 (Ki=0.085 nM) and D2 (Ki=0.49 nM) receptors, and moderate affinity for the 5-HT1A receptor (Ki=2.6 nM) .

• Product Name Alternative:

  RGH-188

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  5-HT Receptor; Dopamine Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/Cariprazine.html

• Purity:

  99.67

• Solubility:

  DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C(N[C@H]1CC[C@H](CCN2CCN(C3=CC=CC(Cl)=C3Cl)CC2)CC1)N(C)C

• Molecular Formula:

  C21H32Cl2N4O

• Molecular Weight:

  427.41

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Seneca N, et al. Occupancy of dopamine D2 and D3 and serotonin 5-HT1A receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using positron emission tomography. Psychopharmacology (Berl) . 2011 Dec;218 (3) :579-8|[2]Kiss B, et al. Cariprazine (RGH-188), a dopamine D (3) receptor-preferring, D (3) /D (2) dopamine receptor antagonist-partial agonist antipsychotic candidate: in vitro and neurochemical profile. J Pharmacol Exp Ther. 2010 Apr;333 (1) :328-40.|[3]Zimnisky R, et al. Cariprazine, a dopamine D (3) -receptor-preferring partial agonist, blocks phencyclidine-induced impairments of working memory, attention set-shifting, and recognition memory in the mouse. Psychopharmacology (Berl) . 2013 Mar;226 (1) :91-100|[4]Gao Y, et al. Cariprazine exerts antimanic properties and interferes with dopamine D2 receptor β-arrestin interactions. Pharmacol Res Perspect. 2015 Feb;3 (1) :e00073.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Launched

• Isoform:

  5-HT1 Receptor; D2 Receptor; D3 Receptor; mLAG-3

• CAS Number:

  839712-12-8