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FBH1 antibody

CAT: 0710-FNab03039Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab03039Size:100 µg
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Background
3'-5' DNA helicase and substrate-recognition component of the SCF (FBXO18) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (PubMed:11956208, PubMed:23393192) . Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination (PubMed:17724085, PubMed:19736316) . Also promotes cell death and DNA double-strand breakage in response to replication stress: together with MUS81, promotes the endonucleolytic DNA cleavage following prolonged replication stress via its helicase activity, possibly to eliminate cells with excessive replication stress (PubMed:23319600, PubMed:23361013) . Plays a major role in remodeling of stalled DNA forks by catalyzing fork regression, in which the fork reverses and the two nascent DNA strands anneal (PubMed:25772361) . In addition to the helicase activity, also acts as the substrate-recognition component of the SCF (FBXO18) E3 ubiquitin ligase complex, a complex that mediates ubiquitination of RAD51, leading to regulate RAD51 subcellular location (PubMed:25585578) .
Synonyms
F-box DNA helicase 1 (hFBH1) |DNA 3'-5' helicase 1|F-box only protein 18|FBH1|FBX18|FBXO18
Gene ID
84893
UniProt
Q8NFZ0
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
F-box protein, helicase, 18
Target
FBH1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
118-123 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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