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F7 antibody

CAT: 0710-FNab02924Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02924Size:100 µg
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Background
Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.
Synonyms
Coagulation factor VII|Proconvertin|Serum prothrombin conversion accelerator (SPCA) |Factor VII light chain|Factor VII heavy chain|F7
Gene ID
2155
UniProt
P08709
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Coagulation factor VII (serum prothrombin conversion accelerator)
Target
F7
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Immunology, Cardiovascular, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
49-55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

UniProtKB · P08709

Coagulation factor VII

FA7_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08709
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
F7
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.4.21.21
Processing
Precursor
Secondary accessions
B0YJC8, Q14339, Q5JVF1, Q5JVF2, Q9UD52, Q9UD53, Q9UD54
Protein keywords

Technical term

3D-structureDirect protein sequencingPharmaceuticalProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Blood coagulationHemostasis

Ligand

Calcium

PTM

Cleavage on pair of basic residuesDisulfide bondGamma-carboxyglutamic acidGlycoproteinHydroxylationZymogen

Disease

Disease variant

Domain

EGF-like domainRepeatSignal

Molecular function

HydrolaseProteaseSerine protease

Cellular component

Secreted

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