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ESR2 antibody

CAT: 0710-FNab02867Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02867Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560) . Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
Synonyms
Estrogen receptor beta (ER-beta) |Nuclear receptor subfamily 3 group A member 2|ESR2|ESTRB|NR3A2
Gene ID
2100
UniProt
Q92731
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Estrogen receptor 2 (ER beta)
Target
ESR2
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB
Field of Research
Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience, Cell Division and Proliferation
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
0A10
Tested Applications
ELISA, WB
Immunogen Sequence
1-300aa

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