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ESR1 antibody

CAT: 0710-FNab02822Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02822Size:100 µg
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Background
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined.
Synonyms
Estrogen receptor (ER) |ER-alpha|Estradiol receptor|Nuclear receptor subfamily 3 group A member 1|ESR1|ESR|NR3A1
Gene ID
2099
UniProt
P03372
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Estrogen receptor 1
Target
ESR1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Signal Transduction, Metabolism, Immunology, Cancer, Developmental biology, Neuroscience, Cell Division and Proliferation
Purification
Immunogen affinity purified
Dilution
WB: 1:1000 - 1:4000; IHC: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB
Immunogen Sequence
1-200aa

UniProtKB · P03372

Estrogen receptor

ESR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P03372
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ESR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ER
EC number
—
Processing
—
Secondary accessions
Q13511, Q14276, Q5T5H7, Q6MZQ9, Q9NU51, Q9UDZ7, Q9UIS7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Molecular function

ActivatorDNA-bindingReceptor

Coding sequence diversity

Alternative promoter usageAlternative splicing

Cellular component

Cell membraneCytoplasmGolgi apparatusMembraneNucleus

Disease

Disease variantOsteoporosis

PTM

GlycoproteinLipoproteinMethylationPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

TransmembraneZinc-finger

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