ERLIN1 antibody

• Background :

  Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) . Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex (PubMed:24217618) .

• Synonyms :

  Erlin-1|Endoplasmic reticulum lipid raft-associated protein 1|Protein KE04|Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1 (SPFH domain-containing protein 1) |ERLIN1|C10orf69|KE04|KEO4|SPFH1

• Gene ID :

  10613

• UniProt :

  O75477

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  ER lipid raft associated 1

• Target :

  ERLIN1

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IP, IF

• Field of Research :

  Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  39 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IP, IF