ERK1/2 antibody

This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene.

Mitogen-activated protein kinase 1 (MAP kinase 1, MAPK 1) |ERT1|Extracellular signal-regulated kinase 2 (ERK-2) |MAP kinase isoform p42 (p42-MAPK) |Mitogen-activated protein kinase 2 (MAP kinase 2, MAPK 2) |MAPK1|ERK2|PRKM1|PRKM2

5594

P28482

Human, Mouse, Rat

Mitogen-activated protein kinase 1

ERK1/2

ELISA, WB, IHC

Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience, Cell Division and Proliferation

Immunogen affinity purified

WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

≥95% as determined by SDS-PAGE

Liquid

40 kDa

4°C with ice bag

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)