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ERI1 antibody

CAT: 0710-FNab02843Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02843Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi) . Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Synonyms
3'-5' exoribonuclease 1|3'-5' exonuclease ERI1|Eri-1 homolog|Histone mRNA 3'-end-specific exoribonuclease|Histone mRNA 3'-exonuclease 1|Protein 3'hExo (HEXO) |ERI1|3'EXO|THEX1
Gene ID
90459
UniProt
Q8IV48
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Exoribonuclease 1
Target
ERI1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
46 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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