Hex

• Description :

  Hex is an enolase inhibitor and antimalarial agent with Ki values of 74.4 nM and 269.4 nM for ENO2 and ENO1, respectively. Hex is a NfENO and TbENO inhibitor with IC50s value of 0.14 μM and 2.1 μM, respectively. Hex has antimalarial activity against Plasmodium falciparum 3D7, Naegleria fowleri trophozoites and Plasmodium berghei ANKA strain. Hex has anti-tumor effects against intracranial tumors[1][2][3][4][5][6][7][8].

• UNSPSC :

  12352005

• Target :

  Enolase; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Metabolic Enzyme/Protease

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/hex.html

• Purity :

  99.96

• Solubility :

  DMSO : 140 mg/mL (ultrasonic)

• Smiles :

  OP(O)(C1C(N(O)CCC1)=O)=O

• Molecular Formula :

  C5H10NO5P

• Molecular Weight :

  195.11

• References & Citations :

  [1]BOARD OF REGENTS, et al. Enolase inhibitors and methods of treatment there with. WO2016145113A1|[2]Lin YH, et al. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 Dec;2 (12) :1413-1426. |[3]Milanes JE, et al. Enolase inhibitors as therapeutic leads for Naegleria fowleri infection. PLoS Pathog. 2024 Aug 1;20 (8) :e1012412.|[4]Roster CP, et al. Enolase Inhibitors as Early Lead Therapeutics against Trypanosoma brucei. Pathogens. 2023 Oct 28;12 (11) :1290.|[5]Yan VC, et al. Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration. ACS Pharmacol Transl Sci. 2023 Jan 6;6 (2) :245-252. |[6]Lin Y H, et al. Eradication of ENO1-deleted glioblastoma through collateral lethality. BioRxiv, 2018: 331538.|[7]Jezewski A J, et al. Accelerated erythrocyte senescence causes dose-limiting anemia of antimalarial enolase inhibitors. Hematology. American Society of Hematology. Education Program, 2020. |[8]Jezewski AJ, et al. Targeting Host Glycolysis as a Strategy for Antimalarial Development. Front Cell Infect Microbiol. 2021 Sep 16;11:730413.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2004714-32-1]