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EIF2AK1 antibody

CAT: 0710-FNab02690Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02690Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells (RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions (By similarity) .
Synonyms
Eukaryotic translation initiation factor 2-alpha kinase 1|Heme-controlled repressor (HCR) |Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase|Heme-regulated inhibitor (hHRI) |Hemin-sensitive initiation factor 2-alpha kinase|EIF2AK1|HRI|KIAA1369
Gene ID
27102
UniProt
Q9BQI3
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Eukaryotic translation initiation factor 2-alpha kinase 1
Target
EIF2AK1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Neuroscience, Immunology, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
71 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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