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EED antibody

CAT: 0710-FNab02640Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02640Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Polycomb group (PcG) protein. Component of the PRC2/EED-EZH2 complex, which methylates 'Lys-9' and 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Also recognizes 'Lys-26' trimethylated histone H1 with the effect of inhibiting PRC2 complex methyltransferase activity on nucleosomal histone H3 'Lys-27', whereas H3 'Lys-27' recognition has the opposite effect, enabling the propagation of this repressive mark. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.
Synonyms
Polycomb protein EED (hEED) |Embryonic ectoderm development protein|WD protein associating with integrin cytoplasmic tails 1 (WAIT-1) |EED
Gene ID
8726
UniProt
O75530
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Embryonic ectoderm development
Target
EED
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Stem Cells, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
53 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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