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E2F1 antibody

CAT: 0710-FNab02600Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02600Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812) .
Synonyms
Transcription factor E2F1 (E2F-1) |PBR3|Retinoblastoma-associated protein 1 (RBAP-1) |Retinoblastoma-binding protein 3 (RBBP-3) |pRB-binding protein E2F-1|E2F1|RBBP3
Gene ID
1869
UniProt
Q01094
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
E2F transcription factor 1
Target
E2F1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC, WB
Field of Research
Cell Division and Proliferation, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
55 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC, WB

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