DYNC1LI1 antibody

• Background:

  Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. Probably involved in the microtubule-dependent transport of pericentrin. Is required for progress through the spindle assembly checkpoint. The phosphorylated form appears to be involved in the selective removal of MAD1L1 and MAD1L2 but not BUB1B from kinetochores.

• Synonyms:

  Cytoplasmic dynein 1 light intermediate chain 1 (LIC1) |Dynein light chain A (DLC-A) |Dynein light intermediate chain 1, cytosolic (DLIC-1) |DYNC1LI1|DNCLI1

• Gene ID:

  51143

• UniProt:

  Q9Y6G9

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  Dynein, cytoplasmic 1, light intermediate chain 1

• Target:

  DYNC1LI1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Signal Transduction, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  57-60 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB