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DROSHA antibody

CAT: 0710-FNab02540Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02540Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ribonuclease III double-stranded (ds) RNA-specific endoribonuclease that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DROSHA cleaves the 3' and 5' strands of a stem-loop in pri-miRNAs (processing center 11 bp from the dsRNA-ssRNA junction) to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. Involved also in pre-rRNA processing. Cleaves double-strand RNA and does not cleave single-strand RNA. Involved in the formation of GW bodies.
Synonyms
Ribonuclease 3|Protein Drosha|Ribonuclease III (RNase III) |p241|DROSHA|RN3|RNASE3L|RNASEN
Gene ID
29102
UniProt
Q9NRR4
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ribonuclease type III, nuclear
Target
DROSHA
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
90 kDa, 151 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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