DOC2B antibody

• Background :

  Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity) .

• Synonyms :

  Double C2-like domain-containing protein beta (Doc2-beta) |DOC2B|DOC2BL

• Gene ID :

  8447

• UniProt :

  Q14184

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Double C2-like domains, beta

• Target :

  DOC2B

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IF

• Field of Research :

  Neuroscience

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:2000; IF: 1:20-1:200

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  46 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IF