DKC1 antibody

• Background:

  This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs) . This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants.

• Synonyms:

  H/ACA ribonucleoprotein complex subunit DKC1|CBF5 homolog|Dyskerin|Nopp140-associated protein of 57 kDa|Nucleolar protein NAP57|Nucleolar protein family A member 4|snoRNP protein DKC1|DKC1|NOLA4

• Gene ID:

  1736

• UniProt:

  O60832

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Dyskeratosis congenita 1, dyskerin

• Target:

  DKC1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Cell Division and Proliferation, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  58 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF