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DICER1 antibody

CAT: 0710-FNab02387Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02387Size:100 µg
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Background
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. Alternative splicing results in multiple transcript variants.
Synonyms
Endoribonuclease Dicer|Helicase with RNase motif (Helicase MOI) |DICER1|DICER|HERNA|KIAA0928
Gene ID
23405
UniProt
Q9UPY3
Host
Rabbit
Reactivity
Human, Mouse, Rat, Monkey
Immunogen
Dicer 1, ribonuclease type III
Target
DICER1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Epigenetics, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:1000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
220-250 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

UniProtKB · Q9UPY3

Endoribonuclease Dicer

DICER_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9UPY3
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DICER1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.26.3
Processing
—
Secondary accessions
A7E2D3, B3KRG4, E0AD28, O95943, Q9UQ02
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingMagnesiumManganeseMetal-bindingNucleotide-binding

Cellular component

Cytoplasm

Disease

Disease variant

Molecular function

EndonucleaseHelicaseHydrolaseNucleaseRNA-binding

Biological process

Host-virus interactionRNA-mediated gene silencing

PTM

Phosphoprotein

Domain

Repeat

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