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DDR1 antibody

CAT: 0710-FNab02291Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02291Size:100 µg
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Background
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity) . Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
Synonyms
Epithelial discoidin domain-containing receptor 1 (Epithelial discoidin domain receptor 1) |CD167 antigen-like family member A|Cell adhesion kinase|Discoidin receptor tyrosine kinase|HGK2|Mammary carcinoma kinase 10 (MCK-10) |Protein-tyrosine kinase 3A|Protein-tyrosine kinase RTK-6|TRK E|Tyrosine kinase DDR|Tyrosine-protein kinase CAK|DDR1|CAK|EDDR1|NEP|NTRK4|PTK3A|RTK6|TRKE
Gene ID
780
UniProt
Q08345
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Discoidin domain receptor tyrosine kinase 1
Target
DDR1
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, IHC
Field of Research
Immunology, Cardiovascular, Metabolism, Signal Transduction
Purification
Immunogen affinity purified
Dilution
IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, IHC
Immunogen Sequence
82-295aa

UniProtKB · Q08345

Epithelial discoidin domain-containing receptor 1

DDR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q08345
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DDR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Epithelial discoidin domain receptor 1
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B5A975, B5A976, B7Z2K0, Q14196, Q16562, Q2L6H3, Q4LE50, Q5ST11, Q5ST12, Q6NSK4, Q9UD35, Q9UD36, Q9UD37, Q9UD86, Q9UDL2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-binding

Cellular component

Cell membraneMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Biological process

LactationPregnancy

Domain

SignalTransmembraneTransmembrane helix

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