CYLD antibody

• Background :

  Protease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Has endodeubiquitinase activity. Plays an important role in the regulation of pathways leading to NF-kappa-B activation (PubMed:12917689, PubMed:12917691) . Contributes to the regulation of cell survival, proliferation and differentiation via its effects on NF-kappa-B activation (PubMed:12917690) . Negative regulator of Wnt signaling (PubMed:20227366) . Inhibits HDAC6 and thereby promotes acetylation of alpha-tubulin and stabilization of microtubules (PubMed:19893491) . Plays a role in the regulation of microtubule dynamics, and thereby contributes to the regulation of cell proliferation, cell polarization, cell migration, and angiogenesis (PubMed:18222923, PubMed:20194890) . Required for normal cell cycle progress and normal cytokinesis (PubMed:17495026, PubMed:19893491) . Inhibits nuclear translocation of NF-kappa-B. Plays a role in the regulation of inflammation and the innate immune response, via its effects on NF-kappa-B activation (PubMed:18636086) . Dispensable for the maturation of intrathymic natural killer cells, but required for the continued survival of immature natural killer cells. Negatively regulates TNFRSF11A signaling and osteoclastogenesis (By similarity) . Involved in the regulation of ciliogenesis, allowing ciliary basal bodies to migrate and dock to the plasma membrane; this process does not depend on NF-kappa-B activation (By similarity) .

• Synonyms :

  Ubiquitin carboxyl-terminal hydrolase CYLD|Deubiquitinating enzyme CYLD|Ubiquitin thioesterase CYLD|Ubiquitin-specific-processing protease CYLD|CYLD|CYLD1|KIAA0849

• UniProt :

  Q9NQC7

• Host :

  Rabbit

• Reactivity :

  Human, Mouse, Rat

• Immunogen :

  Cylindromatosis (turban tumor syndrome)

• Target :

  CYLD

• Clonality :

  Polyclonal

• Isotype :

  IgG

• Applications :

  ELISA, WB, IHC, IP

• Field of Research :

  Epigenetics, Immunology, Metabolism

• Purification :

  Immunogen affinity purified

• Dilution :

  WB: 1:500-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500

• Purity :

  ≥95% as determined by SDS-PAGE

• Form :

  Liquid

• Molecular Weight :

  110 kDa

• Shipping Conditions :

  4°C with ice bag

• Storage Conditions :

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications :

  ELISA, WB, IHC, IP