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CUL2 antibody

CAT: 0710-FNab02074Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02074Size:100 µg
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Background
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity) . The functional specificity of the ECS complex depends on the substrate recognition component. ECS (VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF) .
Synonyms
Cullin-2 (CUL-2) |CUL2
Gene ID
8453
UniProt
Q13617
Host
Rabbit
Reactivity
Human
Immunogen
Cullin 2
Target
CUL2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF, IP
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
87 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF, IP

UniProtKB · Q13617

Cullin-2

CUL2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13617
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CUL2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CUL-2
EC number
—
Processing
—
Secondary accessions
B3KT95, B7Z6K8, D3DRY6, G3V1S2, O00200, Q5T2B6, Q9UNF9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Coding sequence diversity

Alternative splicing

Biological process

Host-virus interactionUbl conjugation pathway

Cellular component

Nucleus

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