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CTNNA1 antibody

CAT: 0710-FNab02056Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab02056Size:100 µg
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Background
Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E-and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.
Synonyms
Catenin alpha-1|Alpha E-catenin|Cadherin-associated protein|Renal carcinoma antigen NY-REN-13|CTNNA1
Gene ID
1495
UniProt
P35221
Host
Mouse
Reactivity
Human, Mouse
Immunogen
Catenin (cadherin-associated protein), alpha 1, 102kDa
Target
CTNNA1
Clonality
Monoclonal
Isotype
IgG1
Applications
ELISA, WB, IHC
Field of Research
Cancer, Signal Transduction, stem cells
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:50-1:1000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
95-100 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
0A11
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
200-536aa

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