CTDSP2 antibody

• Background:

  Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.

• Synonyms:

  Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2|Nuclear LIM interactor-interacting factor 2 (NLI-interacting factor 2) |Protein OS-4|Small C-terminal domain phosphatase 2|Small CTD phosphatase 2 (SCP2) |CTDSP2|NIF2|OS4|SCP2

• Gene ID:

  10106

• UniProt:

  O14595

• Host:

  Rabbit

• Reactivity:

  Human

• Immunogen:

  CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2

• Target:

  CTDSP2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000; IHC: 1:20-1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  31 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC