CLK2 antibody

• Background:

  Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.

• Synonyms:

  Dual specificity protein kinase CLK2|CDC-like kinase 2|CLK2

• Gene ID:

  1196

• UniProt:

  P49760

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  CDC-like kinase 2

• Target:

  CLK2

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA