CLK2 antibody

CAT: 0710-FNab01766Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab01766Size:100 µg
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Background
Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine-and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.
Synonyms
Dual specificity protein kinase CLK2|CDC-like kinase 2|CLK2
Gene ID
1196
UniProt
P49760
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
CDC-like kinase 2
Target
CLK2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA
Field of Research
Metabolism
Purification
Immunogen affinity purified
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA

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