DDIT3 antibody

• Background:

  CHOP, also known as GADD153 or DDIT3, is a highly conserved gene in both the structural and regulatory regions to hamster gene.Imposed by unfolded and malfolded proteins, CHOP is significantly induced by ER stress, deficiency of CHOP prevents cell from ER stress. CHOP is considered a proapoptotic marker of ER stress dependent cell death. CHOP acts as a dominant-negative inhibitor of the transcription factor C/EBP and LAP by forming a heterodimer. It may play an important role in the malignant transformation of nevus to melanoma.

• Synonyms:

  DNA damage-inducible transcript 3 protein (DDIT-3) |C/EBP zeta|C/EBP-homologous protein (CHOP) |C/EBP-homologous protein 10 (CHOP-10) |CCAAT/enhancer-binding protein homologous protein|Growth arrest and DNA damage-inducible protein GADD153|DDIT3|CHOP|CHOP10|GADD153

• Gene ID:

  1649

• UniProt:

  P35638

• Host:

  Mouse

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  DNA-damage-inducible transcript 3

• Target:

  DDIT3

• Clonality:

  Monoclonal

• Isotype:

  IgG2a

• Applications:

  ELISA, WB

• Field of Research:

  Epigenetics, Stem Cells, Metabolism

• Purification:

  Protein A+G purification

• Dilution:

  WB: 1:500-1:5000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  30 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Clone ID:

  5H7

• Tested Applications:

  ELISA, WB

• Immunogen Sequence:

  1-169aa