CHMP4B antibody

• Background:

  This gene encodes a member of the chromatin-modifying protein/charged multivesicular body protein (CHMP) protein family. The protein is part of the endosomal sorting complex required for transport (ESCRT) complex III (ESCRT-III), which functions in the sorting of endocytosed cell-surface receptors into multivesicular endosomes. The ESCRT machinery also functions in the final abscisson stage of cytokinesis and in the budding of enveloped viruses such as HIV-1. The three proteins of the CHMP4 subfamily interact with programmed cell death 6 interacting protein (PDCD6IP, also known as ALIX), which also functions in the ESCRT pathway. The CHMP4 proteins assemble into membrane-attached 5-nm filaments that form circular scaffolds and promote or stabilize outward budding. These polymers are proposed to help generate the luminal vesicles of multivesicular bodies. Mutations in this gene result in autosomal dominant posterior polar cataracts.

• Synonyms:

  Charged multivesicular body protein 4b|Chromatin-modifying protein 4b (CHMP4b) |SNF7 homolog associated with Alix 1|SNF7-2 (hSnf7-2) |Vacuolar protein sorting-associated protein 32-2 (Vps32-2, hVps32-2) |CHMP4B|C20orf178|SHAX1

• Gene ID:

  128866

• UniProt:

  Q9H444

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Chromatin modifying protein 4B

• Target:

  CHMP4B

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC

• Field of Research:

  Signal Transduction, Cell Division and Proliferation

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  35 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC