CHEK1 antibody

CAT: 0710-FNab01653Size: 100 µgDry Ice: NoHazardous: No
CAT#:0710-FNab01653Size:100 µg
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Background
HEK1 (Checkpoint kinase-1) is also named as CHK1 and belongs to the protein kinase superfamily. It is implicated in a circuit in which it activates checkpoints, DNA repair and proliferating cell nuclear antigen and FANCD2 monoubiquitinylation (PMID:21389083) . CHEK1 protects vertebrate cells against spontaneous chromosome missegregation and is required to sustain anaphase delay when spindle function is disrupted by taxol (PMID:17276342) . It has 3 isoforms produced by alternative splicing with the molecular mass of 54 kDa, 44 kDa and 50 kDa.
Synonyms
Serine/threonine-protein kinase Chk1|CHK1 checkpoint homolog|Cell cycle checkpoint kinase|Checkpoint kinase-1|CHEK1|CHK1
Gene ID
1111
UniProt
O14757
Host
Mouse
Reactivity
Human, Mouse, Rat
Immunogen
CHK1 checkpoint homolog
Target
CHEK1
Clonality
Monoclonal
Isotype
IgG2a
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction, Metabolism, Cancer, Developmental biology, Cell Division and Proliferation
Purification
Protein A+G purification
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
50 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Clone ID
9F10
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
42-256aa

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