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CBFA2T3 antibody

CAT: 0710-FNab01316Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01316Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097) . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097) . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity) . Plays a role in granulocyte differentiation (PubMed:15231665) . Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486) .
Synonyms
Protein CBFA2T3|MTG8-related protein 2|Myeloid translocation gene on chromosome 16 protein (hMTG16) |Zinc finger MYND domain-containing protein 4|CBFA2T3|MTG16|MTGR2|ZMYND4
Gene ID
863
UniProt
O75081
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Core-binding factor, runt domain, alpha subunit 2; translocated to, 3
Target
CBFA2T3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
62-65 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB

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