CBFA2T3 antibody

• Background:

  Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097) . Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097) . Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity) . Plays a role in granulocyte differentiation (PubMed:15231665) . Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486) .

• Synonyms:

  Protein CBFA2T3|MTG8-related protein 2|Myeloid translocation gene on chromosome 16 protein (hMTG16) |Zinc finger MYND domain-containing protein 4|CBFA2T3|MTG16|MTGR2|ZMYND4

• Gene ID:

  863

• UniProt:

  O75081

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Core-binding factor, runt domain, alpha subunit 2; translocated to, 3

• Target:

  CBFA2T3

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB

• Field of Research:

  Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:2000

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  62-65 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB