Products for Research Use Only
RegisterLogin

CBFA2T2 antibody

CAT: 0710-FNab01315Size: 100 µgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0710-FNab01315Size:100 µg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Via association with PRDM14 is involved in regulation of embryonic stem cell (ESC) pluripotency (PubMed:27281218) . Involved in primordial germ cell (PCG) formation. Stabilizes PRDM14 and OCT4 on chromatin in a homooligomerization-dependent manner (By similarity) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 (AML1-MTG8/ETO fusion protein) which is produced in acute myeloid leukemia with the chromosomal translocation t (8;21) . May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Through heteromerization with CBFA2T3/MTG16 may be involved in regulation of the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity) . Required for the maintenance of the secretory cell lineage in the small intestine. Can inhibit Notch signaling probably by association with RBPJ and may be involved in GFI1-mediated Paneth cell differentiation (By similarity) .
Synonyms
Protein CBFA2T2|ETO homologous on chromosome 20|MTG8-like protein|MTG8-related protein 1|Myeloid translocation-related protein 1|p85|CBFA2T2|EHT|MTGR1
Gene ID
9139
UniProt
O43439
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Core-binding factor, runt domain, alpha subunit 2; translocated to, 2
Target
CBFA2T2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:2000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
85 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

Related Products

CatalogName
FNab01316CBFA2T3 antibody
P9518-01Recombinant Human CBFA2T3
FNab11062CA125 antibody (capture antibody)
FNab11061CA125 antibody (detection antibody)
FNab11059AFP antibody (detection antibody)
FNab11046-01CEA antibody (capture antibody)
FNab11060AFP antibody (capture antibody)
FNab11045-01CEA antibody (detection antibody)
FNab09471WAS antibody
FNab11063CA19-9 antibody (detection antibody)

Alternative Products

CatalogName
abx028691-01Protein CBFA2T2 (CBFA2T2) Antibody
A06858Anti-Protein CBFA2T2 CBFA2T2 Antibody
GWB-MM810ICBFA2T2 Antibody

Popular Products