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CACNA1B antibody

CAT: 0710-FNab01171Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab01171Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. N-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-IIIA (omega-Aga-IIIA) . They are however insensitive to dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA) . Calcium channels containing alpha-1B subunit may play a role in directed migration of immature neurons.
Synonyms
Voltage-dependent N-type calcium channel subunit alpha-1B|Brain calcium channel III (BIII) |Calcium channel, L type, alpha-1 polypeptide isoform 5|Voltage-gated calcium channel subunit alpha Cav2.2|CACNA1B|CACH5|CACNL1A5
Gene ID
774
UniProt
Q00975
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Calcium channel, voltage-dependent, N type, alpha 1B subunit
Target
CACNA1B
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience
Purification
Immunogen affinity purified
Dilution
WB: 1:200-1:1000; IHC: 1:50-1:500
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
262 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC
Immunogen Sequence
Synthetic peptide, a sequence within amino acids 2200 to the C-terminus

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