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BVES antibody

CAT: 0710-FNab00992Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00992Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells (PubMed:16188940) . Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca (2+) -independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading (By similarity) . Important for the maintenance of cardiac function. Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:26642364) . Is also a caveolae-associated protein important for the preservation of caveolae structural and functional integrity as well as for heart protection against ischemia injury.
Synonyms
Blood vessel epicardial substance (hBVES) |Popeye domain-containing protein 1 (Popeye protein 1) |BVES|POP1|POPDC1
Gene ID
11149
UniProt
Q8NE79
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Blood vessel epicardial substance
Target
BVES
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Stem Cells, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:100-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
41-70 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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