BEST1 antibody

CAT: 0710-FNab00865Size: 100 µgDry Ice: NoHazardous: No

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CAT#:0710-FNab00865Size:100 µg

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Background

This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.

Synonyms

Bestrophin-1|TU15B|Vitelliform macular dystrophy protein 2|BEST1|VMD2

Gene ID

7439

UniProt

O76090

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Bestrophin 1

Target

BEST1

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB, IHC

Field of Research

Neuroscience

Purification

Immunogen affinity purified

Dilution

WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Purity

≥95% as determined by SDS-PAGE

Form

Liquid

Molecular Weight

70 kDa

Shipping Conditions

4°C with ice bag

Storage Conditions

PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Tested Applications

ELISA, WB, IHC

Immunogen Sequence

200-300aa

UniProtKB · O76090

Bestrophin-1

BEST1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: O76090
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: BEST1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: A8K0W6, B7Z3J8, B7Z736, O75904, Q53YQ9, Q8IUR9, Q8IZ80

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumChloride

Cellular component

Cell membraneMembrane

Molecular function

Chloride channelIon channel

Disease

Disease variantRetinitis pigmentosa

Biological process

Ion transportSensory transductionTransportVision

PTM

Phosphoprotein

Domain

TransmembraneTransmembrane helix

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MBS2521144-01	BEST1 Antibody