Products for Research Use Only

BCR antibody

CAT: 0710-FNab00854Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00854Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms
Breakpoint cluster region protein|Renal carcinoma antigen NY-REN-26|BCR|BCR1|D22S11
Gene ID
613
UniProt
P11274
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Breakpoint cluster region
Target
BCR
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
150 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC