BACE1 antibody

• Background:

  Responsible for the proteolytic processing of the amyloid precursor protein (APP) . Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.

• Synonyms:

  Beta-secretase 1|Aspartyl protease 2 (ASP2, Asp 2) |Beta-site amyloid precursor protein cleaving enzyme 1 (Beta-site APP cleaving enzyme 1) |Memapsin-2|Membrane-associated aspartic protease 2|BACE1|BACE|KIAA1149

• Gene ID:

  23621

• UniProt:

  P56817

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Beta-site APP-cleaving enzyme 1

• Target:

  BACE1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IP, IHC

• Field of Research:

  Neuroscience, Metabolism

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500-1:1000; IP: 1:500-1:1000; IHC: 1:100-1:400

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  70-75 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IP, IHC

• Immunogen Sequence:

  150-457aa