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ATXN3 antibody

CAT: 0710-FNab00739Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00739Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ATXN3, which has deubiquitinase activity and act as a component of the ubiquitin proteasome system, plays a role in transcriptional regulation and neuroprotection. ATXN3 interacts with RAD23, HHR23A and HHR23B, involves in the pathology of MJD. ATXN3 is a mixed-linkage, chain-editing enzyme and that the UIM region of ATXN3 regulates its substrate specificity. Contains an N-terminal deubiquitinating domain, called the Josephin domain, followed by 2 ubiquitin-interacting motifs (UIMs) and a polyQ tract near the C terminus. ATXN3 can be phosphorylated in a protein casein kinase-2-dependent manner, thus the MW would be larger than the predicted one.
Synonyms
Ataxin-3|Machado-Joseph disease protein 1|Spinocerebellar ataxia type 3 protein|ATXN3|ATX3|MJD|MJD1|SCA3
UniProt
P54252
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Ataxin 3
Target
ATXN3
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Metabolism, Developmental biology
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:1000; IHC: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
38 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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