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APP antibody

CAT: 0710-FNab00512Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00512Size:100 µg
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Background
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy) . Multiple transcript variants encoding several different isoforms have been found for this gene.
Synonyms
Amyloid-beta precursor protein (APP) |ABPP|APPI|Alzheimer disease amyloid A4 protein homolog|Alzheimer disease amyloid protein|Amyloid precursor protein|Amyloid-beta (A4) precursor protein|Amyloid-beta A4 protein|Cerebral vascular amyloid peptide (CVAP) |PreA4|Protease nexin-II (PN-II) |N-APP|Soluble APP-alpha (S-APP-alpha) |Soluble APP-beta (S-APP-beta) |C99 Alternative names: Beta-secretase C-terminal fragment (Beta-CTF) |Amyloid-beta protein 42 (Abeta42)
Gene ID
351
UniProt
P05067
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
Amyloid beta A4 precursor protein
Target
APP
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC
Field of Research
Neuroscience, Signal Transduction, Metabolism
Purification
Immunogen affinity purified
Dilution
WB: 1:500 - 1:2000; IHC: 1:50 - 1:100
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
110 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC

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