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AGAP2 antibody

CAT: 0710-FNab00205Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0710-FNab00205Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1) -dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.
Synonyms
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) |Centaurin-gamma-1 (Cnt-g1) |GTP-binding and GTPase-activating protein 2 (GGAP2) |Phosphatidylinositol 3-kinase enhancer (PIKE) |AGAP2|CENTG1|KIAA0167
Gene ID
116986
UniProt
Q99490
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
Target
AGAP2
Clonality
Polyclonal
Isotype
IgG
Applications
ELISA, WB, IHC, IF
Field of Research
Signal Transduction
Purification
Immunogen affinity purified
Dilution
WB: 1:500-1:5000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200
Purity
≥95% as determined by SDS-PAGE
Form
Liquid
Molecular Weight
125 kDa
Shipping Conditions
4°C with ice bag
Storage Conditions
PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)
Tested Applications
ELISA, WB, IHC, IF

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