ACOX1 antibody

• Background:

  The protein encoded by this gene is the first enzyme of the fatty acid beta-oxidation pathway, which catalyzes the desaturation of acyl-CoAs to 2-trans-enoyl-CoAs. It donates electrons directly to molecular oxygen, thereby producing hydrogen peroxide. Defects in this gene result in pseudoneonatal adrenoleukodystrophy, a disease that is characterized by accumulation of very long chain fatty acids. Alternatively spliced transcript variants encoding different isoforms have been identified.It has 3 isoforms produced by alternative splicing with the molecular mass of 70-74 kDa and can be cleaved post-translationally into a 50-kDa and a 22-kDa subunit between Val468 and Ala469 (PMID: 10672038) .

• Synonyms:

  Peroxisomal acyl-coenzyme A oxidase 1 (AOX) |Palmitoyl-CoA oxidase|Peroxisomal fatty acyl-CoA oxidase|Straight-chain acyl-CoA oxidase (SCOX) |Peroxisomal acyl-CoA oxidase 1, A chain|Peroxisomal acyl-CoA oxidase 1, B chain|Peroxisomal acyl-CoA oxidase 1, C chain|ACOX1|ACOX

• Gene ID:

  51

• UniProt:

  Q15067

• Host:

  Rabbit

• Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Acyl-Coenzyme A oxidase 1, palmitoyl

• Target:

  ACOX1

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Applications:

  ELISA, WB, IHC, IF

• Field of Research:

  Metabolism, Developmental biology

• Purification:

  Immunogen affinity purified

• Dilution:

  WB: 1:500 - 1:2000; IHC: 1:100 - 1:200; IF: 1:50 - 1:200

• Purity:

  ≥95% as determined by SDS-PAGE

• Form:

  Liquid

• Molecular Weight:

  74 kDa

• Shipping Conditions:

  4°C with ice bag

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

• Tested Applications:

  ELISA, WB, IHC, IF

• Immunogen Sequence:

  1-270aa